Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis

Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis

The aim of this study is to investigate certain genetic features of intrahepatic cholangiocarcinoma (ICCA). A total of 12 eligible ICCA patients were enrolled, and tumor tissues from the patients were subjected to next-generation sequencing of a multi-genes panel. Tumor mutation burden (TMB), mutate...

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Bibliographic Details
Main Authors: Peng Jianbo, Fang Shuo, Li Meisheng, Liu Yuxin, Liang Xiaolu, Li Zuobiao, Chen Gaohui, Peng Lijiao, Chen Nianping, Liu Lei, Xu Xiaohong, Dai Wei
Format: Article
Language:English
Published: De Gruyter 2023-07-01
Series:Open Life Sciences
Subjects:
intrahepatic cholangiocarcinoma
next-generation sequencing
genetic profile
tumor mutation burden
prognosis analysis
Online Access:https://doi.org/10.1515/biol-2022-0652

Internet

https://doi.org/10.1515/biol-2022-0652

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