The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion

The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion

Abstract Malaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the earliest to be associated with malaria prevalence. However, the...

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Bibliographic Details
Main Authors: Viola Introini, Alejandro Marin-Menendez, Guilherme Nettesheim, Yen-Chun Lin, Silvia N. Kariuki, Adrian L. Smith, Letitia Jean, John N. Brewin, David C. Rees, Pietro Cicuta, Julian C. Rayner, Bridget S. Penman
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12060-4

Internet

https://doi.org/10.1038/s41598-022-12060-4

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