Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients

Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients

Abstract Background We previously reported the results of a multicentric prospective randomized trial of chemo-refractory metastatic breast cancer patients testing the efficacy of two doses of TGFβ blockade during radiotherapy. Despite a lack of objective responses to the combination, patients who r...

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Bibliographic Details
Main Authors: Silvia C. Formenti, Rachael E. Hawtin, Neha Dixit, Erik Evensen, Percy Lee, Judith D. Goldberg, Xiaochun Li, Claire Vanpouille-Box, Dörthe Schaue, William H. McBride, Sandra Demaria
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Immunotherapy
Radiotherapy
T cell receptor (TCR) signaling
Programmed Death-1 (PD-1)
Online Access:http://link.springer.com/article/10.1186/s40425-019-0633-x

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http://link.springer.com/article/10.1186/s40425-019-0633-x

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