C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain
Abstract Parkinson’s disease (PD) is the most common neurodegenerative motor disorder, and its pathologic hallmarks include extensive dopaminergic neuronal degeneration in the Substantia nigra associated with Lewy bodies, predominantly consisting of phosphorylated and truncated α-Synuclein (α-Syn)....
Main Authors: | Hualong Wang, Guiqin Chen, Eun Hee Ahn, Yiyuan Xia, Seong Su Kang, Xia Liu, Chang Liu, Ming-Hu Han, Shengdi Chen, Keqiang Ye |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-01-01
|
Series: | npj Parkinson's Disease |
Online Access: | https://doi.org/10.1038/s41531-022-00430-8 |
Similar Items
-
Gut microbiota dysbiosis contributes to α-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson's disease
by: Xiaoli Fang, et al.
Published: (2024-01-01) -
Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo
by: Jie Xiang, et al.
Published: (2024-03-01) -
Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice
by: Yiyuan Xia, et al.
Published: (2023-09-01) -
Gut-to-Brain α-Synuclein Transmission in Parkinson’s Disease: Evidence for Prion-like Mechanisms
by: Merry Chen, et al.
Published: (2023-04-01) -
The Role of α-Synuclein Oligomers in Parkinson’s Disease
by: Xiao-yu Du, et al.
Published: (2020-11-01)