The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia

The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia

Ribosomal biogenesis involves the processing of pre-ribosomal RNA. A deficiency of some ribosomal proteins (RPs) impairs processing and causes Diamond Blackfan anemia (DBA), which is associated with anemia, congenital malformations and cancer. p53 mediates many features of DBA, but the mechanism of...

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Bibliographic Details
Main Authors: Nadia Danilova, Elena Bibikova, Todd M. Covey, David Nathanson, Elizabeth Dimitrova, Yoan Konto, Anne Lindgren, Bertil Glader, Caius G. Radu, Kathleen M. Sakamoto, Shuo Lin
Format: Article
Language:English
Published: The Company of Biologists 2014-07-01
Series:Disease Models & Mechanisms
Subjects:
Ribosomal protein deficiency
Rps19
Rpl11
p53
ATR
RNR
Chk1
ATP
AMPK
Exogenous nucleosides
Online Access:http://dmm.biologists.org/content/7/7/895

Internet

http://dmm.biologists.org/content/7/7/895

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