Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier

Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier

Abstract Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intestine is unclear. We performed single-nuclear RNA sequencing (snRNAseq) in the pinch biopsies of terminal ileum of four age-matched men [56 years, healthy control, compen...

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Bibliographic Details
Main Authors: Xixian Jiang, Ying Xu, Andrew Fagan, Bhaumik Patel, Huiping Zhou, Jasmohan S. Bajaj
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell & Bioscience
Subjects:
Hepatic encephalopathy
Infections
Decompensation
Mucus layer
Rifaximin
Defensin
Online Access:https://doi.org/10.1186/s13578-024-01209-5

Internet

https://doi.org/10.1186/s13578-024-01209-5

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