Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation.

Mechanical strain plays a critical role in the proliferation, differentiation and maturation of bone cells. As mechanical receptor cells, osteoblasts perceive and respond to stress force, such as those associated with compression, strain and shear stress. However, the underlying molecular mechanisms...

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Bibliographic Details
Main Authors: Yu-xian Yan, Yuan-wei Gong, Yong Guo, Qi Lv, Chun Guo, Yan Zhuang, Yuan Zhang, Ruixin Li, Xi-zheng Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22539993/?tool=EBI