Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence

Abstract Osteoarthritis (OA) is an age-related degenerative joint disease that causes progressive cartilage loss. Chondrocyte senescence is a fundamental mechanism that contributes to the imbalance of matrix homeostasis in OA by inducing senescence-associated secretory phenotype (SASP). Although OA...

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Bibliographic Details
Main Authors: Misaki Yagi, Kentaro Endo, Keiichiro Komori, Ichiro Sekiya
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34825-1