Novel Polymeric Hybrid Nanocarrier for Curcumin and Survivin shRNA Co-delivery Augments Tumor Penetration and Promotes Synergistic Tumor Suppression

Novel Polymeric Hybrid Nanocarrier for Curcumin and Survivin shRNA Co-delivery Augments Tumor Penetration and Promotes Synergistic Tumor Suppression

A major barrier for co-delivery of gene medicine with small molecular chemotherapeutic drugs in solid tumors is the inadequate tumor penetration and transfection. In this study, a novel polymeric nanocarrier with integrated properties of tumor penetration, nuclear targeting, and pH-responsive featur...

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Bibliographic Details
Main Authors: Bei Xu, Wen Zhou, Lizhi Cheng, Yang Zhou, Aiping Fang, Chaohui Jin, Jun Zeng, Xiangrong Song, Xia Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Chemistry
Subjects:
curcumin
survivin shRNA
co-delivery
tumor penetration
nuclear targeting
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00762/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00762/full

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