Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy

Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy

Context Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-inflammatory and antioxidative effects. Objective To explore the neuroprotective effect of SPJ on natural ageing of rat. Materials and methods Sprague-Dawley (SD)...

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Bibliographic Details
Main Authors: Xue-Jiao Pi, Qing-Qing Zhao, Jin-Xin Wang, Xu-Lan Zhang, Ding Yuan, Shan-Shan Hu, Yu-Min He, Chang-Cheng Zhang, Zhi-Yong Zhou, Ting Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
neuroinflamamtion
cognitive function
microglia
m1-like phenotype
m2-like phenotype
Online Access:http://dx.doi.org/10.1080/13880209.2021.1961824

Internet

http://dx.doi.org/10.1080/13880209.2021.1961824

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