Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile

Sphingosine 1 phosphate (S1P) lyase (<i>Sgpl1</i>) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation. Loss of <i>Sgpl1</i> in humans and mice leads to accumulation of sphingolipids and multiple organ injuries. Here, we addressed...

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Bibliographic Details
Main Authors: Anna Katharina Spohner, Katja Jakobi, Sandra Trautmann, Dominique Thomas, Fabian Schumacher, Burkhard Kleuser, Dieter Lütjohann, Khadija El-Hindi, Sabine Grösch, Josef Pfeilschifter, Julie D. Saba, Dagmar Meyer zu Heringdorf
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine-1-phosphate
SGPL1
ceramides
cholesterol
liver
bile
Online Access:https://www.mdpi.com/1422-0067/22/19/10617

Internet

https://www.mdpi.com/1422-0067/22/19/10617

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