Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection

Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection

Humanized bone marrow-liver-thymus (HuBLT) mice are a revolutionary small-animal model that has facilitated the study of human immune function and human-restricted pathogens, including human immunodeficiency virus type 1 (HIV-1). These mice recapitulate many aspects of acute and chronic HIV-1 infect...

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Bibliographic Details
Main Authors: Wilfredo F. Garcia-Beltran, Daniel T. Claiborne, Colby R. Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall E. Karpel, Katharine L. Krupp, Karen A. Power, Christian L. Boutwell, Alejandro B. Balazs, Andrew M. Tager, Marcus Altfeld, Todd M. Allen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
innate immunity
T cells
HIV-1
HuBLT
BLT
humanized mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.667393/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.667393/full

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