Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures.

Differentiated neurons can be rapidly acquired, within days, by inducing stem cells to express neurogenic transcription factors. We developed a protocol to maintain long-term cultures of human neurons, called iNGNs, which are obtained by inducing Neurogenin-1 and Neurogenin-2 expression in induced p...

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Bibliographic Details
Main Authors: Rebecca S Lam, Felix M Töpfer, Phillip G Wood, Volker Busskamp, Ernst Bamberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5215418?pdf=render