WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer

WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer

Abstract Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clinical trials. In a survey for potential combination th...

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Bibliographic Details
Main Authors: Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M Virshup, Babita Madan
Format: Article
Language:English
Published: Springer Nature 2021-04-01
Series:EMBO Molecular Medicine
Subjects:
BRCA1
DNA repair
ETC‐1922159
FANCD2
homologous recombination
Online Access:https://doi.org/10.15252/emmm.202013349

Internet

https://doi.org/10.15252/emmm.202013349

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