Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma

Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma

Abnormal DNA methylation has been observed in multiple malignancies, including melanoma. In this study, we initially noticed the overexpression of DNA methyltransferase 1 (DNMT1) in melanoma samples in bioinformatics analysis and, subsequently, validated it in the purchased melanoma cell lines. Afte...

Full description

Bibliographic Details
Main Authors: Yemei Yang, Shengfang Ma, Zi Ye, Yushi Zheng, Zhenjiong Zheng, Xiongshan Liu, Xianyi Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Epigenetics
Subjects:
melanoma
dna methyltransferase 1
heat shock protein b8
bcl2-associated athanogene 3
autophagy
pi3k/akt/mtor pathway
apoptosis
Online Access:http://dx.doi.org/10.1080/15592294.2023.2239607

Internet

http://dx.doi.org/10.1080/15592294.2023.2239607

Similar Items