Epithelial and Mesenchymal-like Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Associated with Different Metastatic Propensities

Epithelial and Mesenchymal-like Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Associated with Different Metastatic Propensities

Pancreatic ductal adenocarcinoma (PDAC) is mostly diagnosed at advanced or even metastasized stages, limiting the prognoses of patients. Metastasis requires high tumor cell plasticity, implying phenotypic switching in response to changing environments. Here, epithelial–mesenchymal transition (EMT),...

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Bibliographic Details
Main Authors: Lisa-Marie Philipp, Umut-Ulas Yesilyurt, Arne Surrow, Axel Künstner, Anne-Sophie Mehdorn, Charlotte Hauser, Jan-Paul Gundlach, Olga Will, Patrick Hoffmann, Lea Stahmer, Sören Franzenburg, Hendrike Knaack, Udo Schumacher, Hauke Busch, Susanne Sebens
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
pancreatic adenocarcinoma
PDAC
cancer stem cells
EMT
epithelial–mesenchymal-transition
heterogeneity
Online Access:https://www.mdpi.com/2072-6694/16/4/686

Internet

https://www.mdpi.com/2072-6694/16/4/686

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