Single-Cell Transcriptomes Combining with Consecutive Genomics Reveal Clonal Evolution and Gene Regulatory Networks in Relapsed and Refractory Multiple Myeloma

Single-Cell Transcriptomes Combining with Consecutive Genomics Reveal Clonal Evolution and Gene Regulatory Networks in Relapsed and Refractory Multiple Myeloma

This study attempted to investigate how clonal structure evolves, along with potential regulatory networks, as a result of multiline therapies in relapsed/refractory multiple myeloma (RRMM). Eight whole exome sequencing (WES) and one single cell RNA sequencing (scRNA-seq) were performed in order to...

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Bibliographic Details
Main Authors: Jiadai Xu, Yue Wang, Zheng Wei, Jingli Zhuang, Jing Li, Yifeng Sun, Liang Ren, Yawen Wang, Panpan Li, Shiyang Gu, Yian Zhang, Jifeng Jiang, Chen Chen, Yu Zhang, Peng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
multiple myeloma
clonal evolution
relapsed
refractory
heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.794144/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.794144/full

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