D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia

D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia

Summary: Degeneration of dopaminergic neurons leads to Parkinson’s disease (PD), characterized by reduced levels of striatal dopamine (DA) and impaired voluntary movements. DA replacement is achieved by levodopa treatment which in long-term causes involuntary movements or dyskinesia. Dyskinesia is l...

Full description

Bibliographic Details
Main Authors: Ermanno Florio, Marcello Serra, Robert G. Lewis, Enikö Kramár, Michael Freidberg, Marcello Wood, Micaela Morelli, Emiliana Borrelli
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Behavioral neuroscience
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222015358

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222015358

Similar Items