Characterization of the Immune Response to PD-1 Blockade during Chemoradiotherapy for Head and Neck Squamous Cell Carcinoma

Characterization of the Immune Response to PD-1 Blockade during Chemoradiotherapy for Head and Neck Squamous Cell Carcinoma

Background: Chemoradiotherapy is a standard treatment for HNSCC. Blockade of the PD-1/L1-2 interaction may represent a target to overcome immune escape during this treatment. Methods: Utilizing a HNSCC mEERL C57BL/6 mouse model, we evaluated a PD-1 blockade alone or in combination with cisplatin-bas...

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Bibliographic Details
Main Authors: Juan L. Callejas-Valera, Daniel W. Vermeer, Christopher T. Lucido, Caitlin Williamson, Marisela Killian, Paola D. Vermeer, William C. Spanos, Steven F. Powell
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
head and neck cancer
immunotherapy
PD-1
chemoradiotherapy
T cells
HNSCC
Online Access:https://www.mdpi.com/2072-6694/14/10/2499

Internet

https://www.mdpi.com/2072-6694/14/10/2499

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