The emerging role of fumarate as an oncometabolite

The emerging role of fumarate as an oncometabolite

The drive to understand how altered cellular metabolism and cancer are linked has caused a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic enzyme, isocitrate dehydrogenase 1 (IDH1), that leads to accumulation of the oncometabolite 2-hydroxyglutarate, provided sig...

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Bibliographic Details
Main Authors: Ming eYang, Tomoyoshi eSoga, Patrick John Pollard, Julie eAdam
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Oncology
Subjects:
Cancer
Mitochondrial dysfunction
Oncometabolite
succination
fumarate
dysregulated metabolism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00085/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00085/full

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