The emerging role of fumarate as an oncometabolite
The drive to understand how altered cellular metabolism and cancer are linked has caused a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic enzyme, isocitrate dehydrogenase 1 (IDH1), that leads to accumulation of the oncometabolite 2-hydroxyglutarate, provided sig...
| Автори: | , , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Frontiers Media S.A.
2012-07-01
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| Серія: | Frontiers in Oncology |
| Предмети: | |
| Онлайн доступ: | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00085/full |