Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states

Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states

Summary: Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer with identical affinity (Kd ∼2 nM). Contrary...

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Bibliographic Details
Main Authors: Ravi Jasuja, Daniel Spencer, Abhilash Jayaraj, Liming Peng, Meenakshi Krishna, Brian Lawney, Priyank Patel, Bhyravabhotla Jayaram, Kelly M. Thayer, David L. Beveridge, Shalender Bhasin
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Biochemistry
Endocrinology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003825

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http://www.sciencedirect.com/science/article/pii/S2589004221003825

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