Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity

Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity

Abstract Background Spaceflight and microgravity environments have been shown to cause significant health impairments, including bone loss, immune dysfunction, and hematopoietic disorders. Hematopoietic stem cells (HSCs), as progenitors of the hematopoietic system, are critical for the continuous re...

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Bibliographic Details
Main Authors: Xiru Liu, Hao Zhang, Jinxiao Yan, Penghui Ye, Yanran Wang, Nu Zhang, Zhenhao Tian, Bin Liu, Hui Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Microgravity
Hindlimb unloading
HSCs
Proliferation
Differentiation
Online Access:https://doi.org/10.1186/s13287-025-04213-9

Internet

https://doi.org/10.1186/s13287-025-04213-9

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