Canagliflozin reverses Th1/Th2 imbalance and promotes podocyte autophagy in rats with membranous nephropathy

Canagliflozin reverses Th1/Th2 imbalance and promotes podocyte autophagy in rats with membranous nephropathy

Idiopathic membranous nephropathy is the main cause of chronic kidney disease (CKD). Studies have shown sodium–glucose co-transporter 2 (SGLT2) inhibitors significantly delay renal outcomes in patients with CKD, but the exact mechanism remains unknown. In this study, we investigated the mechanism by...

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Bibliographic Details
Main Authors: Xin Lv, Jian Wang, Li Zhang, Xian Shao, Yao Lin, Hongyan Liu, Guangyang Ma, Jing Li, Saijun Zhou, Pei Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
membranous nephropathy (MN)
canagliflozin
T-cells
B-cells
podocyte autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.993869/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.993869/full

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