Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus

Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus

Severe influenza associated with strong symptoms and lung inflammation can be caused by intra-host evolution of quasispecies with aspartic acid or glycine in hemagglutinin position 222 (HA-222D/G; H1 numbering). To gain insights into the dynamics of host response to this coevolution and to identify...

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Bibliographic Details
Main Authors: Himanshu Manchanda, Nora Seidel, Markus Blaess, Ralf Alexander Claus, Jörg Linde, Hortense Slevogt, Andreas Sauerbrei, Reinhard Guthke, Michaela Schmidtke
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Microbiology
Subjects:
Computational Biology
Gene Expression
Pneumonia
mouse model
trasncriptomics
viral pathogenesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01167/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01167/full

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