Small, Cationic Antifungal Proteins from Filamentous Fungi Inhibit Candida albicans Growth in 3D Skin Infection Models

Small, Cationic Antifungal Proteins from Filamentous Fungi Inhibit Candida albicans Growth in 3D Skin Infection Models

ABSTRACT The emerging resistance of human-pathogenic fungi to antifungal drugs urges the development of alternative therapeutic strategies. The small, cationic antifungal proteins (AFPs) from filamentous ascomycetes represent promising candidates for next-generation antifungals. These bio-molecules...

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Bibliographic Details
Main Authors: Jeanett Holzknecht, Sandrine Dubrac, Sarah Hedtrich, László Galgóczy, Florentine Marx
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
3D skin infection model
Candida albicans
full-thickness model
Neosartorya (Aspergillus) fischeri
Penicillium chrysogenum
antifungal proteins
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00299-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00299-22

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