HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve

HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve

HIF1A is significantly upregulated in calcified human aortic valves (AVs). Furthermore, HIF1A inhibitor PX-478 was shown to inhibit AV calcification under static and disturbed flow conditions. Since elevated stretch is one of the major mechanical stimuli for AV calcification, we investigated the eff...

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Bibliographic Details
Main Authors: Md Tausif Salim, Nicolas Villa-Roel, Booth Vogel, Hanjoong Jo, Ajit P. Yoganathan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cyclic stretch
HIF1A
PX-478
aortic valve
calcification
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1002067/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.1002067/full

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