Biosynthetic L-tert-leucine using Escherichia coli co-expressing a novel NADH-dependent leucine dehydrogenase and a formate dehydrogenase

Biosynthetic L-tert-leucine using Escherichia coli co-expressing a novel NADH-dependent leucine dehydrogenase and a formate dehydrogenase

Background: L-tert-Leucine has been widely used in pharmaceutical, chemical, and other industries as a vital chiral intermediate. Compared with chemical methods, enzymatic methods to produce L-tert-leucine have unparalleled advantages. Previously, we found a novel leucine dehydrogenase from the halo...

Full description

Bibliographic Details
Main Authors: Longxing Wang, Wenjun Zhu, Zhen Gao, Hua Zhou, Fei Cao, Min Jiang, Yan Li, Honghua Jia, Ping Wei
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Electronic Journal of Biotechnology
Subjects:
Chiral intermediate
Formate dehydrogenase
Laceyella sacchari
Leucine dehydrogenase
L-tert-leucine
Reductive amination
Online Access:http://www.sciencedirect.com/science/article/pii/S0717345820300324

Internet

http://www.sciencedirect.com/science/article/pii/S0717345820300324

Similar Items