Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy associated with HTLV-1

Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy associated with HTLV-1

Human T-lymphotropic virus 1 (HTLV-1) infection causes two serious diseases: adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). Immunological studies have revealed that HTLV-1 Tax-specific CD8+ cytotoxic T-cells (Tax-CTLs) in asymptomatic carriers (ACs) and ATL patients pla...

Full description

Bibliographic Details
Main Authors: Yukie Tanaka, Tomoo Sato, Naoko Yagishita, Junji Yamauchi, Natsumi Araya, Satoko Aratani, Katsunori Takahashi, Yasuo Kunitomo, Misako Nagasaka, Yoshinobu Kanda, Kaoru Uchimaru, Tomohiro Morio, Yoshihisa Yamano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
tax
T-cell receptor repertoire
Cytotoxic T-cell
CSF
HAM
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.993025/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.993025/full

Similar Items