Effects of senataxin and RNA exosome on B-cell chromosomal integrity

Effects of senataxin and RNA exosome on B-cell chromosomal integrity

Loss of function of senataxin (SETX), a bona-fide RNA/DNA helicase, is associated with neuronal degeneration leading to Ataxia and Ocular Apraxia (AOA) in human patients. SETX is proposed to promote transcription termination, DNA replication, DNA repair, and to unwind deleterious RNA:DNA hybrids in...

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Bibliographic Details
Main Authors: David Kazadi, Junghyun Lim, Gerson Rothschild, Veronika Grinstein, Brice Laffleur, Olivier Becherel, Martin J. Lavin, Uttiya Basu
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Heliyon
Subjects:
Biological sciences
Immunology
Genetics
Biochemistry
Molecular biology
RNA exosome
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020302875

Internet

http://www.sciencedirect.com/science/article/pii/S2405844020302875

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