P38 Mediates Tumor Suppression through Reduced Autophagy and Actin Cytoskeleton Changes in NRAS-Mutant Melanoma

P38 Mediates Tumor Suppression through Reduced Autophagy and Actin Cytoskeleton Changes in NRAS-Mutant Melanoma

Hotspot mutations in the NRAS gene are causative genetic events associated with the development of melanoma. Currently, there are no FDA-approved drugs directly targeting NRAS mutations. Previously, we showed that p38 acts as a tumor suppressor in vitro and in vivo with respect to NRAS-mutant melano...

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Bibliographic Details
Main Authors: Ishani Banik, Adhideb Ghosh, Erin Beebe, Blaž Burja, Mojca Frank Bertoncelj, Christopher M. Dooley, Enni Markkanen, Reinhard Dummer, Elisabeth M. Busch-Nentwich, Mitchell P. Levesque
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
melanoma
NRAS mutation
p38 tumor suppressor
mTOR
autophagy
anisomycin
Online Access:https://www.mdpi.com/2072-6694/15/3/877

Internet

https://www.mdpi.com/2072-6694/15/3/877

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