A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion

A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion

Abstract 22q11.2 deletion syndrome, associated with congenital and neuropsychiatric anomalies, is the most common copy number variant (CNV)-associated syndrome. Patient-derived, induced pluripotent stem cell (iPS) models have provided insight into this condition. However, patient-derived iPS cells m...

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Bibliographic Details
Main Authors: Neha Paranjape, Yu-Hsiu T. Lin, Quetzal Flores-Ramirez, Vishesh Sarin, Amanda Brooke Johnson, Julia Chu, Mercedes Paredes, Arun P. Wiita
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34325-2

Internet

https://doi.org/10.1038/s41598-023-34325-2

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