Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber.

The cornea is a central component of the camera eye of vertebrates and even slight corneal disturbances severely affect vision. The transcription factor PAX6 is required for normal eye development, namely the proper separation of the lens from the developing cornea and the formation of the iris and...

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Main Authors: Masanari Takamiya, Benjamin D Weger, Simone Schindler, Tanja Beil, Lixin Yang, Olivier Armant, Marco Ferg, Günther Schlunck, Thomas Reinhard, Thomas Dickmeis, Sepand Rastegar, Uwe Strähle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0117645