The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

ABSTRACT Alpaca-derived single-domain antibody fragments (VHHs) that target the influenza A virus nucleoprotein (NP) can protect cells from infection when expressed in the cytosol. We found that one such VHH, αNP-VHH1, exhibits antiviral activity similar to that of Mx proteins by blocking nuclear im...

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Bibliographic Details
Main Authors: Leo Hanke, Kevin E. Knockenhauer, R. Camille Brewer, Eline van Diest, Florian I. Schmidt, Thomas U. Schwartz, Hidde L. Ploegh
Format: Article
Language:English
Published: American Society for Microbiology 2016-12-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01569-16

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https://journals.asm.org/doi/10.1128/mBio.01569-16

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