Pathogenic Variations of Homologous Recombination Gene HSF2BP Identified in Sporadic Patients With Premature Ovarian Insufficiency

Pathogenic Variations of Homologous Recombination Gene HSF2BP Identified in Sporadic Patients With Premature Ovarian Insufficiency

Premature ovarian insufficiency (POI) is defined as depletion of ovarian function before 40 years of age, which affects 3.7% of women in reproductive age. The etiology of POI is heterogeneous. Recently, with the widespread use of whole-exome sequencing (WES), the DNA repair genes, especially for tho...

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Bibliographic Details
Main Authors: Shan Li, Weiwei Xu, Bingying Xu, Shuchang Gao, Qian Zhang, Yingying Qin, Ting Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
premature ovarian insufficiency
homologous recombination
HSF2BP
whole-exome sequencing
gene mutation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.768123/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.768123/full

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