Simvastatin pretreatment ameliorates t-PA–induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats

Simvastatin pretreatment ameliorates t-PA–induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats

Bo Yin,*,1 Dan-Dong Li,*,2,3 Shang-Yu Xu,3 Huan Huang,4 Jian Lin,3 Han-Song Sheng,3 Jun-Hao Fang,3 Jin-Ning Song,2 Ming Zhang11Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Departm...

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Bibliographic Details
Main Authors: Yin B, Li DD, Xu SY, Huang H, Lin J, Sheng HS, Fang JH, Song JN, Zhang M
Format: Article
Language:English
Published: Dove Medical Press 2019-07-01
Series:Neuropsychiatric Disease and Treatment
Subjects:
simvastatin
acute ischemic stroke
t-PA
MMP-9/TIMP-1
Rho/ROCK pathway
hemorrhagic transformation
Online Access:https://www.dovepress.com/simvastatin-pretreatment-ameliorates-t-pandashinduced-hemorrhage-trans-peer-reviewed-article-NDT

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https://www.dovepress.com/simvastatin-pretreatment-ameliorates-t-pandashinduced-hemorrhage-trans-peer-reviewed-article-NDT

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