Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.

Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.

Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert α-ketoglutarate to 2-hydroxyglutarate, ultimately leading to tumorigenesis. The major source of 2-hydroxyglutarate pro...

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Bibliographic Details
Main Authors: Jose L Izquierdo-Garcia, Larry M Cai, Myriam M Chaumeil, Pia Eriksson, Aaron E Robinson, Russell O Pieper, Joanna J Phillips, Sabrina M Ronen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4171511?pdf=render

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http://europepmc.org/articles/PMC4171511?pdf=render

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