Fixed low dose versus concentration-controlled initial tacrolimus dosing with reduced target levels in the course after kidney transplantation: results from a prospective randomized controlled non-inferiority trial (Slow & Low study)Research in context

Fixed low dose versus concentration-controlled initial tacrolimus dosing with reduced target levels in the course after kidney transplantation: results from a prospective randomized controlled non-inferiority trial (Slow & Low study)Research in context

Summary: Background: Optimal initial tacrolimus dosing and early exposure of tacrolimus after renal transplantation is not well studied. Methods: In this open-label, 6 months, multicenter, randomized controlled, non-inferiority study, we randomly assigned 432 renal allograft recipients to receive b...

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Bibliographic Details
Main Authors: Julian Stumpf, Klemens Budde, Oliver Witzke, Claudia Sommerer, Thomas Vogel, Peter Schenker, Rainer Peter Woitas, Mirian Opgenoorth, Evelyn Trips, Eva Schrezenmeier, Christian Hugo, Matthias Girndt, Gunter Wolf, Christine Kurschat, Kai Lopau, Jens Lutz
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:EClinicalMedicine
Subjects:
Renal transplantation
Tacrolimus monitoring
Fixed low dose
Immunosuppression
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537023005588

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http://www.sciencedirect.com/science/article/pii/S2589537023005588

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