Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages

Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages

IntroductionLipoprotein(a) (Lp(a)) is an LDL-like particle with an additional apolipoprotein (apo)(a) covalently attached. Elevated levels of circulating Lp(a) are a risk factor for atherosclerosis. A proinflammatory role for Lp(a) has been proposed, but its molecular details are incompletely define...

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Bibliographic Details
Main Authors: Martina B. Lorey, Amer Youssef, Lauri Äikäs, Matthew Borrelli, Martin Hermansson, Julia M. Assini, Aapeli Kemppainen, Hanna Ruhanen, Maija Ruuth, Sampsa Matikainen, Petri T. Kovanen, Reijo Käkelä, Michael B. Boffa, Marlys L. Koschinsky, Katariina Öörni
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
inflammation
lipoprotein(a)
apolipoproteins
atherosclerotic cardiovascular disease
atherosclerosis
caspase-1
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1130162/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1130162/full

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