Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure

Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure

Abstract Background Long-term exposure to fine particulate matter (PM2.5) increases susceptibility to chronic respiratory diseases, including inflammation and interstitial fibrosis. However, the regulatory mechanisms by which the immune response mediates the initiation of pulmonary fibrosis has yet...

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Bibliographic Details
Main Authors: Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng, Daochuan Li, Wen Chen
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Particle and Fibre Toxicology
Subjects:
Particle matter
Chronic lung injuries
Single-cell RNA sequencing
IL-17A
Myeloid-derived suppressor cells
Online Access:https://doi.org/10.1186/s12989-022-00483-w

Internet

https://doi.org/10.1186/s12989-022-00483-w

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