Direct visualization of protease action on collagen triple helical structure.

Enzymatic processing of extracellular matrix (ECM) macromolecules by matrix metalloproteases (MMPs) is crucial in mediating physiological and pathological cell processes. However, the molecular mechanisms leading to effective physiological enzyme-ECM interactions remain elusive. Only scant informati...

Full description

Bibliographic Details
Main Authors: Gabriel Rosenblum, Philippe E Van den Steen, Sidney R Cohen, Arkady Bitler, David D Brand, Ghislain Opdenakker, Irit Sagi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20585385/pdf/?tool=EBI