Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia

Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia

Objective: Adipose tissue is the largest endocrine organ. When activated by cancer cells, adipocytes secrete adipocytokines and release fatty acids, which are then transferred to cancer cells and used for structural and biochemical support. How this metabolic symbiosis between cancer cells and adipo...

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Bibliographic Details
Main Authors: Mengistu Lemecha, Jaya Prakash Chalise, Yuki Takamuku, Guoxiang Zhang, Takahiro Yamakawa, Garrett Larson, Keiichi Itakura
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
Cachexia
Thermogenesis
BAT
Lcn2
PDAC
Hypothermia
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001818

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http://www.sciencedirect.com/science/article/pii/S2212877822001818

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