Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts

Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts

Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e.g., endothelial cells, fibroblasts, and immune cells). Adipose tissue also represents a crucial...

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Bibliographic Details
Main Authors: Elena Andreucci, Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Alessio Biagioni, Eloisa Romano, Lido Calorini, Mirko Manetti
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
adipocytes
adipose-derived stem cells
cell differentiation
extracellular acidosis
lactate
myofibroblasts
Online Access:https://www.mdpi.com/2073-4409/12/6/939

Internet

https://www.mdpi.com/2073-4409/12/6/939

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