Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma

Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (cSCC) is the second most frequent of the keratinocyte-derived malignancies with actinic keratosis (AK) as a precancerous lesion. To comprehensively delineate the underlying mechanisms for the whole progression from normal skin to AK to invasive cSCC, we performed s...

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Bibliographic Details
Main Authors: Dan-Dan Zou, Ya-Zhou Sun, Xin-Jie Li, Wen-Juan Wu, Dan Xu, Yu-Tong He, Jue Qi, Ying Tu, Yang Tang, Yun-Hua Tu, Xiao-Li Wang, Xing Li, Feng-Yan Lu, Ling Huang, Heng Long, Li He, Xin Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
single-cell transcriptome
actinic keratosis
cutaneous squamous cell carcinoma
keratinocyte
tumor microenvironment
Online Access:https://elifesciences.org/articles/85270

Internet

https://elifesciences.org/articles/85270

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