Clonorchis sinensis infection induces hepatobiliary injury via disturbing sphingolipid metabolism and activating sphingosine 1-phosphate receptor 2

Clonorchis sinensis infection induces hepatobiliary injury via disturbing sphingolipid metabolism and activating sphingosine 1-phosphate receptor 2

Clonorchis sinensis (C. sinensis) infection induces severe hepatobiliary injuries, which can cause inflammation, periductal fibrosis, and even cholangiocarcinoma. Sphingolipid metabolic pathways responsible for the generation of sphingosine-1-phosphate (S1P) and its receptor S1P receptors (S1PRs) ha...

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Bibliographic Details
Main Authors: Ji-Xin Liu, Man Liu, Guo-Zhi Yu, Qian-Qian Zhao, Jian-Ling Wang, Yan-Hong Sun, Stephane Koda, Beibei Zhang, Qian Yu, Chao Yan, Ren-Xian Tang, Zhi-Hua Jiang, Kui-Yang Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Clonorchis sinensis
hepatobiliary injuries
biliary epithelial cells (BECs)
sphingolipid metabolism
sphingosine 1-phosphate receptor 2
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1011378/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.1011378/full

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