Antioxidative Sirt1 and the Keap1-Nrf2 Signaling Pathway Impair Inflammation and Positively Regulate Autophagy in Murine Mammary Epithelial Cells or Mammary Glands Infected with <i>Streptococcus uberis</i>

Antioxidative Sirt1 and the Keap1-Nrf2 Signaling Pathway Impair Inflammation and Positively Regulate Autophagy in Murine Mammary Epithelial Cells or Mammary Glands Infected with <i>Streptococcus uberis</i>

<i>Streptococcus uberis</i> mastitis in cattle infects mammary epithelial cells. Although oxidative responses often remove intracellular microbes, <i>S. uberis</i> survives, but the mechanisms are not well understood. Herein, we aimed to elucidate antioxidative mechanisms dur...

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Bibliographic Details
Main Authors: Sohrab Khan, Tian Wang, Eduardo R. Cobo, Bingchun Liang, Muhammad Asfandyar Khan, Maolin Xu, Weijie Qu, Jian Gao, Herman W. Barkema, John P. Kastelic, Gang Liu, Bo Han
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Antioxidants
Subjects:
bovine mastitis
<i>Streptococcus uberis</i>
antioxidative pathway
inflammation
autophagy
murine mammary glands
Online Access:https://www.mdpi.com/2076-3921/13/2/171

Internet

https://www.mdpi.com/2076-3921/13/2/171

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