Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied quantitative in vitro–in vivo extrapolation (QIVIVE) based on in vitro concentration and non-choline ester...

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Bibliographic Details
Main Authors: Engi Abdelhady Algharably, Emma Di Consiglio, Emanuela Testai, Francesca Pistollato, Anna Bal-Price, Abdulkarim Najjar, Reinhold Kreutz, Ursula Gundert-Remy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
PBK modelling
reverse dosimetry
animal alternative
dose-response modeling
organophosphorus pesticides
new approach methodologies (NAMs)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1136174/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1136174/full

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