Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied quantitative in vitro–in vivo extrapolation (QIVIVE) based on in vitro concentration and non-choline ester...

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Dades bibliogràfiques
Autors principals: Engi Abdelhady Algharably, Emma Di Consiglio, Emanuela Testai, Francesca Pistollato, Anna Bal-Price, Abdulkarim Najjar, Reinhold Kreutz, Ursula Gundert-Remy
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2023-03-01
Col·lecció:Frontiers in Pharmacology
Matèries:
PBK modelling
reverse dosimetry
animal alternative
dose-response modeling
organophosphorus pesticides
new approach methodologies (NAMs)
Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2023.1136174/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1136174/full

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