Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α<sub>4</sub>β<sub>1</sub> Integrin

Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α<sub>4</sub>β<sub>1</sub> Integrin

Integrin receptors mediate cell–cell interactions via the recognition of cell-adhesion glycoproteins, as well as via the interactions of cells with proteins of the extracellular matrix, and upon activation they transduce signals bi-directionally across the cell membrane. In the case of injury, infec...

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Bibliographic Details
Main Authors: Monica Baiula, Michele Anselmi, Francesco Musiani, Alessia Ghidini, Jacopo Carbone, Alberto Caligiana, Andrea Maurizio, Santi Spampinato, Luca Gentilucci
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
VLA-4
leukocytes
peptidomimetics
antagonists
molecular modelling
inflammation
Online Access:https://www.mdpi.com/1422-0067/24/11/9588

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https://www.mdpi.com/1422-0067/24/11/9588

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