Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait

Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait

Sickle cell disease (SCD) is caused by the homozygous beta-globin gene mutation that can lead to ischemic multi-organ damage and consequently reduce life expectancy. On the other hand, sickle cell trait (SCT), the heterozygous beta-globin gene mutation, is still considered a benign condition. Althou...

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Bibliographic Details
Main Authors: Marcello Trucas, Sabrina Burattini, Susanna Porcu, Michela Simbula, Maria Serafina Ristaldi, Marta Anna Kowalik, Maria Pina Serra, Pietro Gobbi, Michela Battistelli, Andrea Perra, Marina Quartu
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
sickle cell disease
sickle cell trait
morphology
ultrastructure
hematology
transmission electron microscopy
Online Access:https://www.mdpi.com/1422-0067/24/13/10452

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https://www.mdpi.com/1422-0067/24/13/10452

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