High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.

High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.

The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the mechanisms of this intracellular accumulation and exceptional cytotoxicity of maytan...

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Bibliographic Details
Main Authors: Victor S Goldmacher, Charlene A Audette, Yinghua Guan, Eriene-Heidi Sidhom, Jagesh V Shah, Kathleen R Whiteman, Yelena V Kovtun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4324968?pdf=render

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http://europepmc.org/articles/PMC4324968?pdf=render

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